Akagera Medicines’ TB Drug Shows ‘Promising’ Results in Preclinical Trials – International Edition (English)

Rwandan biotechnology firm Akagera Medicines recently reported encouraging outcomes following the conclusion of initial phases of preclinical testing for an antibiotic aimed at treating pulmonary tuberculosis (TB). On Tuesday, April 1st, the company disclosed that they have finished the preliminary stages of their preclinical tests on AKG-100—a newly developed antibiotic within the oxazolidinone category—specifically engineered to combat pulmonary TB.
In related news, Rwanda signed agreements earlier regarding hosting initiatives linked to African pharmaceutical foundations. Additionally, last month saw Akagera Medicines securing $1.5 million to enhance accessibility measures.
Based out of facilities in both Boston and San Francisco alongside owning a wholly-controlled affiliate based in Kigali where operations include production activities along with upcoming clinical studies, the enterprise concentrates on discovering and advancing innovative lipid nanoparticles used not only in antibiotics but also mRNA vaccinations intended to tackle various illnesses such as tuberculosis, bird influenza, respiratory syncytial virus (RSV), among others.
Dr. Daryl Drummond, who serves as the Chief Scientific Officer at Akagera Medicines, highlighted the significance of achieving key benchmarks during these developmental milestones towards introducing advanced long-term injectables tailored explicitly toward aiding individuals suffering from pulmonary TB conditions. According to him, “AKG-100 exhibits strong potential through favorable pre-clinical findings.”
Experts working under the umbrella of Akagera Medicines characterized AKG-100 using terms like ‘extremely stable’ when describing its modified version incorporating polyethylene glycol chains attached to phospholipid bilayers forming nanoscale structures known scientifically as pegylated liposomes.
These specially crafted carriers offer numerous advantages including improved therapeutic effectiveness due primarily to heightened chemical resilience coupled with enhanced aqueous compatibility thus minimizing adverse side effects typically associated with conventional therapies. Furthermore, owing to protective characteristics inherent in liposomal constructs, active substances remain shielded against enzymatic breakdown processes occurring naturally inside human bodies leading ultimately to extended periods wherein effective dosing levels can persist without necessitating frequent administration schedules.
Moreover, investigators involved confirmed that employing this particular approach facilitated more efficient cellular absorption rates accompanied by prolonged intracellular persistence thereby ensuring elevated localized concentration gradients directly impacting afflicted areas effectively. Overall, leveraging advancements made possible via modern nanoengineering techniques presents exciting prospects opening up possibilities hitherto unexplored avenues offering hope particularly amongst those battling severe forms resistant strains prevalent across different parts globally today.

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Power Outages Set for Six Counties on Wednesday — International Edition (English)


Kenya Power has declared planned electricity outages in certain regions throughout the nation, impacting areas within six counties.

The power company outlined regions impacted in Nairobi, Kiambu, Kitui, Tharaka Nithi, Mombasa, and Kwale counties.

A public announcement released on Tuesday evening stated that interruptions would occur at various times.

between 8am and 5pm.

The electricity outage is occurring to enable system upkeep.


Nairobi

Sections of Nairobi will experience electricity outages between 9 am and 5 pm.

The regions include Githurai 45, Co-op Bank, Naivas, Kingdom Sacco, Mount Kenya, Kimbo, Mwana Mukia, Clanne Academy, Kassmatt, Fountain Junior, Kwa DO Mukinye, Army Barracks, Sukari B, Mwiki School, Kimbo Police Station, part of Mwihoko, Farmers Choice, part of Clay City, along with neighboring consumers.

Other zones include Section III of Eastleigh, portions of Yusuf Haji Road, Mega Wholesalers, the Eastleigh Equity Bank, the Huduma Centre in Eastleigh, parts of Eastleigh’s Second Avenue, sections of Eastleigh’s Third Avenue, and nearby clients.

Meanwhile, sections of Evergreen Runda, Flame Tree, Ruaka Road, Runda Meadows, Bombax Drive, and Tala Drive will experience electricity outages in Nairobi.


Kiambu

Sections of Kiambu will experience disruption in electricity supply between 9 AM and 5 PM.

The locations include Ruaka town, Slaughter Road, Kyuna Road, Gertrude, Kinuthia Drive, California, James Drive, a section of the Bypass, Delta, the Total Petrol Station, and nearby clients.


Kitui

Sections of Kitui will experience electricity outages between 9 am and 5 pm.

The locations include Kora Market, Kwa Gavana, Mivukoni, Tseikuru, Kaningo, Usueni, Mikauni, Ngungani Market, Kiambere Water Supply, and Wikithuki.


Mt Kenya region

Areas scheduled for power outages between 9 AM and 5 PM include Kiamuthanga Market, Kiamuthanga Village, Mbogo-Ini Village, Tumutumu Farm, Tumutumu Secondary School, Kiamubira Primary School, Tumutumu Hospital, Kiangoma Village, Karie Coffee Factory, Ikonju Village, Mungaria Coffee Factory, Mungaria Polytechnic, Wakamata Village, Mbari Ya Njora Village, as well as nearby clients using Safaricom and Airtel boosters.

Additional locations scheduled for power outages between 8 AM and 5 PM in the Mount Kenya area encompass Birithia Girls, Mahiga Girls, Gathtuthi Girls, Gathuthi Tea Factory, Ndugamano Market, Kagere Market, Kenyatta Mahiga High School, Gitugi Tea Factory, Ihithe Secondary, Gura Village, Hubuini Market, Mathenge Technical Training Institute, Mahiga Coffee Factory, Kina TBC, Gacami Market, Ndunyu Market, along with nearby consumers.


Tharaka Nithi

Regions within Tharaka Nithi will experience electricity outages between 8:30 AM and 4 PM.

The properties include Godka Hotel, Chuka KPLC office, Chuka Kenya Police station, and neighboring clients.


Mombasa

Sections of Mombasa will face electricity outages between 9 AM and 5 PM.

The list encompasses institutions such as the Technical University of Mombasa, Tudor Sub-County Hospital, locations like Tudor Nora, Rasini Road, areas including Tudor Kwa Mchele, Tudor Kiziwi, educational facilities such as St Joseph Catholic School, places named Tudor Mwisho, landmarks like Kaa Chonjo, residential complexes such as Nyumba ya Wazee, eateries like Kwa Amo Biriyani, recreational spots like Tudor Water Sports, along with nearby patrons.


Kwale

The areas of Kwale expected to experience power disruptions between 9 AM and 4 PM include Mshiu, Mwangwei, Majoreni, Lungalunga, Mwangulu, Mtumwa, Vanga, Horohoro, along with nearby consumers.

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Customs Reject CG Tenure Extension, Expose Report as Fraud

The Nigeria Customs Service has stated that the reported extension of tenure for the Comptroller General of Customs, Adewale Adeniyi, is untrue.

Abdullahi Maiwada, who serves as the National Public Relations Officer for the organization, issued a statement on Tuesday stating that these reports were incorrect and deceptive.

He stated that the President has exclusive authority over the appointment and extension of terms for members of the CGC, as per the guidelines set out in the NCS Act 2023 and other pertinent rules overseeing public sector appointments.

“The National Customs Service has noticed a fraudulent statement purportedly issued by the State House concerning an extension of the term for the CGC, Adewale Adeniyi. The NCS strongly wants to clarify that this information is incorrect and deceptive,” stated Maiwada.

He emphasized again that currently, no such instruction has been passed along to the NCS by the relevant bodies.

Maiwada insisted that the leadership of the organization continues to concentrate on achieving its legal responsibilities which include promoting trade, generating income, and ensuring border safety.

As per his statement, with the oversight of the present CGC, the organization has kept pushing forward significant changes designed to “update customs procedures, boost cooperation among different agencies, and foster the country’s economic development.”

The spokesperson for the NCS requested that both the general public and all involved parties refer solely to official sources for precise details about the organization.

He stressed that any updates about assignments or term decisions will be officially conveyed via the relevant governmental bodies.

“The service values the ongoing support from stakeholders and continues to be dedicated to maintaining transparency, demonstrating professionalism, and serving the nation,” he stated.

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IEV’s Top Picks: Unveiling the $14,000 Riese & Müller Load4 Electric Bike

IEV’s Top Picks: Unveiling the $14,000 Riese & Müller Load4 Electric Bike

We’re testing additional electric bikes and city-friendly transportation options, beginning with this nut-colored cargo vehicle. Feel free to ask us anything.

Electric bikes and overall e-mobility are gaining popularity globally as well as throughout the United States. In 2024, the sale of electric bicycles in the U.S. amounted to almost $1.8 billion, as reported by PeopleForBikes.
survey data
If you broaden this to encompass electric scooters and similar devices, the total figure would likely be even greater. Even Rivian has decided to join this trend.
Also
, its misleadingly titled micro-mobility division.

As denser cities and their neighboring suburbs invest in cycling infrastructure to alleviate traffic congestion and enhance road safety, the shift towards alternative modes of transport for city and short-distance travel becomes logical. The costs associated with cars and related expenditures have surged significantly, making such options increasingly prohibitive.
one in five
first-time car purchasers facing a $1,000 monthly car payment prior to accounting for fuel or insurance costs.
25% tariffs
With new regulations on imported cars and components scheduled to come into play on April 2nd, it seems affordability won’t be improving shortly. For numerous households, an electric bike as an alternative to a second car is becoming increasingly appealing.

Photo by: Maddox Kay/InsideEVs

In other words:
InsideEVs
Is focused on exploring the future of transportation, which now extends beyond just automobiles. Therefore, we intend to use our strict evaluation methods and straightforward feedback for all things related to electric mobility—assisting you in determining which items deserve your attention and which might be unreliable choices.

We’re beginning with this: The Riese & Müller Load4 75 Rohloff HS,
borrowed from Propel Bikes
That sounds complex, so let me break it down. Riese & Müller is a well-established German bicycle manufacturer with over three decades of experience, specializing in premium electric bikes since 2009. The Load4 represents their fourth-generation model in the range of front-loading cargo bicycles, and the “75” denotes the size of the cargo area at 75 centimeters long. Another notable component comes from Rohloff, a different German firm recognized for manufacturing internal gear hubs offering 14 speeds; these systems utilize belts rather than chains and demand less upkeep. Lastly, “HS” stands for High Speed, as this pedelec is capable of reaching up to 28 miles per hour and features an additional Turbo assist setting.

Photo by: Maddox Kay/InsideEVs

Photo by: Maddox Kay/InsideEVs

Photo by: Maddox Kay/InsideEVs

The cost isn’t insignificant—at $14,419 for the model tested, it definitely makes you take notice. This places it at the high-end of the cargo electric bike spectrum, more suited to luxury pursuits rather than budget-conscious buyers. However, equipped with full suspension and featuring 1.45 kWh of battery capacity offering approximately 80 miles of practical range, it transforms into a versatile all-terrain vehicle capable of carrying substantial loads, akin to a small car. Considering its used-car-level pricing, these features become quite significant.

(To be completely transparent: The staff at the electric bike retailer
Propel Bikes
lent me the
Load4
For a few days for this review.)

Photo by: Maddox Kay/InsideEVs

This week, I’ll put my cargo bike through rigorous use: runs to Costco and the garden center, a 20-mile total commute spanning different boroughs, plus leading a “bike bus” for school drop-offs. I will share updates later, but tell me now—what would you like to learn about the Load4 75?

When it comes to initial impressions, this bicycle is remarkably comfortable and steady whether fully loaded or empty. Initially, I was concerned about maneuvering with a large cargo box extending beyond the handlebars, but I adapted swiftly to the bike’s size and impressive handling capabilities. Additionally, the suspension system ensures a smooth journey even across New York City’s rough streets and bumpy pavements. However, the bike can seem lengthy and cumbersome when trying to navigate the tight corridors of my apartment complex.

What do you want to see in our e-bike and micromobility reviews at InsideEVs? Let us hear your thoughts.

AY Makun Challenges Nigerian Banks Over Exorbitant Service Charges

Well-known Nigerian entertainer and movie producer Ayo Makun, widely recognized as AY, has voiced his worries about the high service fees charged by commercial banks in Nigeria.

On his X account (previously known as Twitter), AY raised doubts about how banks can consistently report trillions of Naira in quarterly profits amidst Nigeria’s faltering economy.

He contended that certain fees levied on customers are specific to Nigeria and ought to be contested.

He questioned, “How do banks manage to report trillions in profits each quarter despite a struggling economy? We should challenge the minor charges and deductions from our accounts. These fees often have a specific presence in Nigeria. What explains this?”

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).